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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

May 2025

Volume 2, Issue 5 - $2025

Volume 2 Issue 5 Cover

Issue Details:

Volume 2 Issue 5
Published:Invalid Date

Editorial: May 2025

Welcome to the 2025 issue of Journal of Pharmaceutical Research and Integrated Medical Sciences. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Arpan Kumar Tripathi
Editor-in-Chief
Journal of Pharmaceutical Research and Integrated Medical Sciences

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: JPRIMS520080

Behavioral and Biochemical Analysis of a Dual-Target CNS Agent Using Rodent Maze Models

Deleshwar Kumar

This experimental research explores the therapeutic value of a new dual-target central nervous system (CNS) drug that concurrently regulates GABAergic and glutamatergic systems to treat  co-occurring  cognitive  impairment  and  anxiety  symptoms.  Performed  on  thirty  adults  male  Wistar  rats,  the  study  utilized  proven  behavioural  paradigms  Elevated  Plus  Maze  (EPM)   for anxiety   and   Morris  Water   Maze   (MWM)   for   spatial   learning   along   with    post-mortem biochemical assays to examine acetylcholinesterase (AChE) activity and markers of  oxidative stress  like  malondialdehyde  (MDA)  and  superoxide  dismutase  (SOD).  Results   indicated significant, dose-dependent enhancements: high-dose treatment groups demonstrated increased open-arm  exploration  in  EPM  and  reduced  escape  latencies  with  more  time  spent   in  target quadrants  in  MWM,  indicating  anxiolytic  and  cognitive-enhancing  effects.   Biochemically,  a significant decrease in AChE and MDA levels and increased SOD activity validated  enhanced cholinergic transmission and antioxidant defense. One-way ANOVA validated these results with high statistical significance (p

carbon Tetrachloride (CClâ‚„)- induced Liver ToxicityWistar RatsNovel Polyherbal ExtractHepatoprotectiveDose-Dependent
4,819 views
1,480 downloads

Contributors:

 Deleshwar Kumar
Research PaperID: JPRIMS520081

Comparative Study on Behavioural Changes in Mice Exposed to ProlongedBlue Light Radiation

Govind Sharma

The effects of long term exposure to blue light on a range of behavioural parameters in mice, such as anxiety, locomotor activity, cognition, and sleep patterns is explored in this study. Male mice (30) were subjected to 4 or 8 h of exposure to the blue light every day for two weeks while the control group was kept under normal lighting. To understand anxiety, motor functions, cognitive flexibility, and circadian rhythms, the Open Field Test, Elevated Plus Maze, Y-Maze, and Wheel Running Test was carried out to assess behavioural attributes. The outcomes proved that long-term exposure to blue light caused strong decreases in the locomotor activity and cognitive performance and caused the increase in the anxiety-like behaviours and the interruption of the normal sleep-wake cycles. The results indicate that chronic exposure to blue light may be harmful to both mental and physical health, and may have ramifications for the body particularly with regards to contemporary lifestyles that are reliant on digital-screen and artificial light. This study implies necessity of conducting further researches on long-term influence of blue light on behaviour and the necessity of managing one’s exposure to avoid possible risks.

Rodent Maze ModelsAgentCentral Nervous System (CNS)Dual-TargetBiochemical AnalysisBehavioural
5,018 views
1,469 downloads

Contributors:

 Govind Sharma
Research PaperID: JPRIMS520082

Role Of Dietary Spirulina in Reproductive Potential in Male Albino Rats

Deepak Biswas

This experimental study investigates the effect of dietary Spirulina supplementation on male reproductive health in albino rats. Thirty male rats were divided into three groups: control, low-dose Spirulina, and high-dose Spirulina. For 30 days, the treatment groups were given Spirulina with their food, while the control group was given standard chow. At the termination of supplementation, several reproductive parameters were evaluated such as sperm concentration, motility, morphology, serum testosterone levels, testicular histopathology, and markers of oxidative stress (MDA, SOD, catalase, and GSH). The findings showed remarkably improved sperm quality and testosterone status in Spirulina-treated groups with increased activity of antioxidant enzymes and decreased lipid peroxidation. Histopathological study also showed improved testicular integrity and spermatogenesis. These results indicate that Spirulina exerts a protective and augmenting influence on male fertility, possibly as a result of its strong antioxidant activity. The research highlights the potential of Spirulina as a natural, safe, and inexpensive supplement for reproductive health augmentation, but points to the necessity of further research in models to validate its therapeutic uses.

Locomotor activitySleep disruptionCognitive performanceAnxietylike behaviourMice modelBehavioural health+1 more
5,127 views
1,500 downloads

Contributors:

 Deepak Biswas
Research PaperID: JPRIMS520083

Stability Analysis of Herbal Nasal SpraysUnder Simulated Storage Conditions

Nitita Banafar

The stability of herbal nasal sprays is important for their safety and efficacy during their shelf life. The purpose of this study was to determine the physical, chemical, and microbiological stability of herbal nasal sprays during simulated storage conditions. Nasal sprays were exposed to three temperature conditions: room temperature (25°C), higher temperature (40°C), and cold temperature (4°C) for a period of six months. Physical characteristics including appearance, fragrance, and functionality of spray were tested, together with chemical stability through determination of active ingredient content by high-performance liquid chromatography (HPLC). Stability against microbials was quantified by performing bacterial and fungal count analysis. The findings evidenced little physical loss, with partial reduction in the functionality of the spray at 40°C at three months but no appreciable alteration in stability at room conditions and refrigerated temperatures. Significant active ingredient degradation, though, was noticed at higher temperatures. Microbial growth was not detected under room and refrigerator storage conditions, but traces of increased contamination were noticed at 40°C after six months. One-way ANOVA statistical analysis ensured that storage temperature had a very significant impact on both chemical and microbiological stability. These results indicate that storage at reduced temperatures serves to preserve the stability of herbal nasal sprays, while increased temperatures enhance degradation and impair microbial integrity.

reproductive health.albino ratsantioxidant enzymesoxidative stresstestosterone levelssperm quality+2 more
5,082 views
1,654 downloads

Contributors:

 Nitita Banafar
Research PaperID: JPRIMS520084

Toxicity Evaluation of Textile Effluents on Gill Morphology and Enzyme Activity in Zebrafish

arpan tripathi

In this study, the toxicological effects of textile effluent were studied on zebrafish (Danio rerio) through the examination of morphological and biochemical changes as a result of a 96 hour exposure to low, medium and high concentrations of effluents, when compared to the control group which was maintained in clean and filtered water. Morphological parameters including lamellar length, epithelial lifting, hyperplasia, and lamellar fusion were counted to obtain the Gill Damage Index (GDI), while the activities of catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE) have been measured in order to The results showed dose-dependent fish’s gill damage and enzymatic activity decrease, which attests that textile effluent has both structural and biochemical effects on fish. These results point to the ecological threats of textile wastewater and zebrafish’s abilities as a bioindicator for aquatic environmental monitoring, highlighting the need to enhance effluent management and regulations, that is, timely intervention.

Active Ingredient DegradationMicrobiological StabilityChemical StabilityPhysical StabilityStabilityHerbal Nasal Sprays
5,379 views
1,562 downloads

Contributors:

 arpan tripathi

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