Formulation and Evaluation of Biodegradable, Glucose-Responsive Microneedle Patch for Insulin Delivery inType 1 Diabetes Treatment

This study represents glucose-responsive insulin delivery by a microneedle patch for improved treatment of T1D. In direct response to increased blood glucose levels, insulin is released from the biodegradable glucose-responsive polymers comprising the patch. Results from the in-vitro experiment on synthetic skin models proved very effective; dose-dependent insulin release was measured, with a maximum of up to 90% after 6 hours at 250 mg/dL glucose. In-vivo tests on diabetic rats showed that it reduced blood glucose levels by 50%, which is far better than conventional insulin delivery modes. Histological studies showed no evidence of skin damage. This microneedle patch may provide a more effective and user-friendly alternative to insulin delivery systems.