Lukeshwari Sahu

Poor aqueous solubility is a critical issue in drug development, with implications on bioavailability and therapeutic activity. This research involves formulation and testing of an oral suspension of a poorly water-soluble drug with the aim of improving solubility, stability, and dissolution rates. A total of 20 formulations (F1–F20) were prepared employing different levels of suspending agents, surfactants, and stabilizers. All the formulations were evaluated in quintuplicate (n = 100) for physicochemical properties, in vitro dissolution profiles, and stability at various storage conditions. Formulations F10 and F15 exhibited maximum drug release (97.5% and 95.3% at 120 minutes, respectively) and best stability for 30 days, with negligible pH change and sedimentation volume ratio. Statistical comparison employing ANOVA validated enhanced solubility and dissolution of the drug compared with non-optimized formulations (p

This study represents glucose-responsive insulin delivery by a microneedle patch for improved treatment of T1D. In direct response to increased blood glucose levels, insulin is released from the biodegradable glucose-responsive polymers comprising the patch. Results from the in-vitro experiment on synthetic skin models proved very effective; dose-dependent insulin release was measured, with a maximum of up to 90% after 6 hours at 250 mg/dL glucose. In-vivo tests on diabetic rats showed that it reduced blood glucose levels by 50%, which is far better than conventional insulin delivery modes. Histological studies showed no evidence of skin damage. This microneedle patch may provide a more effective and user-friendly alternative to insulin delivery systems.