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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

January-2025

Volume 2, Issue 1 - $2025

Volume 2 Issue 1 Cover

Issue Details:

Volume 2 Issue 1
Published:Invalid Date

Editorial: January-2025

Welcome to the 2025 issue of Journal of Pharmaceutical Research and Integrated Medical Sciences. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Arpan Kumar Tripathi
Editor-in-Chief
Journal of Pharmaceutical Research and Integrated Medical Sciences

Articles in This Issue

Showing 6 of 6 articles
Research PaperID: JPRIMS120016

Formulation and Evaluation of Lotion Containing Vitamin D To Protect Breast Cancer Patients from Radiation Dermatitis

Mr Deepak Biswas, Vinay Sagar Verma

This study involved developing and evaluating a vitamin D lotion to protect breast cancer patients' skin from radiotherapy-induced dermatitis. This lotion was produced using an emulsion-based system combining vitamin D with excipients for stability and efficacy. Physical and chemical assessments for the lotion in question included pH 5.2, viscosity of 2400 cPs, and spreading pleasingly smoothness. The acceptable range was met; however, sensory testing showed high acceptability scores by patients, as: mean scores were 4.2 for spreadability, 4.4 for absorption, and 4.6 for comfort. Significant reductions in radiation dermatitis severity were established with significant improvement in RTOG/EORTC scores from baseline to week 4: from 3.5 to 1.5, p

RTOG/EORTCVitamin DRadiation DermatitisPatientsBreast Cancer
2,097 views
707 downloads

Contributors:

 Mr Deepak Biswas
,
 Vinay Sagar Verma
Research PaperID: JPRIMS120018

Itraconazole Nanoemulsion Formulation and Assessment for Improved Oral Bioavailability

Rashmi Chanda, Deleshwar Kumar

Itraconazole is a potent antifungal agent, which has poor solubility and high first-pass metabolism, thus limiting its oral bioavailability. The present research work focuses on the enhancement of itraconazole's bioavailability through the formulation and evaluation of a nanoemulsion. A nanoemulsion was prepared with the help of Tween 80, medium-chain triglycerides, and propylene glycol. It was ensured the stability of the drug was ensured through mean particle size, 180 nm, polydispersity index of 0.15, and zeta potential of -22.4 mV. In vitro drug release experiments showed that the amount released was 88% within 4 hours, which is significantly higher compared to the output from the basic suspension with around 50% release. The ex vivo permeation experiments showed improvement in the drug permeability, sixfold. Pharmacokinetic studies in rats demonstrated high values of the obtained peak concentrations C_max of 25.4 μg/ml, and AUC_0-∞ of 110.2 μg·hr/ml. Stability studies from three months' duration showed a broader durability of the formulation. Noticeably, the outcome is a novel agent in this clinical environment that can increase oral bioavailability and simultaneously enhance drug activity.

Polydispersity Index (PDI)Gastrointestinal AbsorptionNanoemulsionFirst-Pass MetabolismBioavailabilityAntifungal Drug+1 more
1,993 views
718 downloads

Contributors:

 Rashmi Chanda
,
 Deleshwar Kumar
Research PaperID: JPRIMS120019

Potential Application of Transdermal Medication Administration Using Insulin Patch Technology to Treat Diabetic Mellitus

Hemkanti Patel, Harshalata Kanwar

This study explores transdermal insulin patch technology as a possible alternative to conventional subcutaneous insulin injections in managing diabetes mellitus. A quasi-experimental design was utilized in this study, comparing the efficacy, safety, patient satisfaction, and adherence of insulin patches with subcutaneous insulin injections. A total of 150 adults, 75 in each group, with a medical diagnosis of either Type 1 or Type 2 diabetes mellitus, were recruited from diabetes management clinics. Glycemic parameters were measured pre- and post-intervention for six months on both groups, including HbA1c and glucose levels while fasting. Results indicated that both the treatment groups revealed significant reductions in HbA1c and fasting glucose. The insulin patch group had an even more pronounced reduction in HbA1c and glucose levels. The insulin patch was well-tolerated, with only 12% of participants experiencing mild skin irritation. Patient satisfaction was significantly higher in the experimental group, with 88% rating the insulin patch as "very convenient" compared to 46% in the control group.

Polydispersity Index (PDI)Gastrointestinal AbsorptionNanoemulsionFirst-Pass MetabolismBioavailabilityAntifungal Drug+1 more
2,367 views
773 downloads

Contributors:

 Hemkanti Patel
,
 Harshalata Kanwar
Research PaperID: JPRIMS120020

Preparation and Characterisation of Several Herbal Ointment Compositions with an Assessment of Antibacterial Properties

Harshlata Kanwar, Rashmi Chanda

This study involved developing and evaluating a vitamin D lotion to protect breast cancer patients' skin from radiotherapy-induced dermatitis. This lotion was produced using an emulsion-based system combining vitamin D with excipients for stability and efficacy. Physical and chemical assessments for the lotion in question included pH 5.2, viscosity of 2400 cPs, and spreading pleasingly smoothness. The acceptable range was met; however, sensory testing showed high acceptability scores by patients, as: mean scores were 4.2 for spreadability, 4.4 for absorption, and 4.6 for comfort. Significant reductions in radiation dermatitis severity were established with significant improvement in RTOG/EORTC scores from baseline to week 4: from 3.5 to 1.5, p

2,636 views
715 downloads

Contributors:

 Harshlata Kanwar
,
 Rashmi Chanda
Research PaperID: JPRIMS120021

Transdermal Use of Curcumin Nanoemulsion: Preparation and Assessment

Neha Mandle, Shahbaz Rathor

Curcuma longa is the natural source of curcumin, a potent polyphenolic molecule with anti- inflammatory,  antioxidant,  and  anticancer  effects.  However,  its  clinical  use  is  severely hampered due to rapid metabolism and low oral bioavailability. Therefore, this research aims to  formulate  a  curcumin  nanoemulsion  that  is  stabilised  with  improved  solubility,  skin penetration, and stability. For this purpose, the nanoemulsion formulation was optimized for stability,  encapsulation  efficiency,  and  particle  size.  The  study  also  evaluates  its  anti- inflammatory  properties,  release  kinetics,  and  skin  penetration. The  results  obtained  were encapsulation efficiency of 85.6 ± 4.3%, zeta potential of -28.4 ± 3.1 mV, and particle size of128.5 ± 6.7 nm. The release kinetics of two formulations followed first-order kinetics, while the  third  formulation  followed  zero-order  kinetics.  The  therapeutic  potency  of  curcumin nanoemulsion in reducing inflammation was validated by substantial reductions in levels of inflammatory biomarkers TNF-α, 38.4%, and IL-6, 42.1% observed in the ex vivo analysis.

Curcuma Longa (Turmeric)Azadirachta Indica (Neem)Aloe Vera.Ocimum Sanctum (Tulsi)AntibacterialHerbal Ointment
2,754 views
807 downloads

Contributors:

 Neha Mandle
,
 Shahbaz Rathor
Research PaperID: JPRIMS120022

Formulation and Evaluation of Biodegradable, Glucose-Responsive Microneedle Patch for Insulin Delivery inType 1 Diabetes Treatment

Lukeshwari Sahu, Sandhya

This study represents glucose-responsive insulin delivery by a microneedle patch for improved treatment of T1D. In direct response to increased blood glucose levels, insulin is released from the biodegradable glucose-responsive polymers comprising the patch. Results from the in-vitro experiment on synthetic skin models proved very effective; dose-dependent insulin release was measured, with a maximum of up to 90% after 6 hours at 250 mg/dL glucose. In-vivo tests on diabetic rats showed that it reduced blood glucose levels by 50%, which is far better than conventional insulin delivery modes. Histological studies showed no evidence of skin damage. This microneedle patch may provide a more effective and user-friendly alternative to insulin delivery systems.

Anti-Inflammatory Effects.Release KineticsSkin PermeationNanoemulsion FormulationMetabolismAnticancer Properties+5 more
2,677 views
777 downloads

Contributors:

 Lukeshwari Sahu
,
 Sandhya

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