carbon Tetrachloride (CCl₄)- induced Liver Toxicity
Explore 1 research publication tagged with this keyword
Publications Tagged with "carbon Tetrachloride (CCl₄)- induced Liver Toxicity"
1 publication found
2025
1 publicationBehavioral and Biochemical Analysis of a Dual-Target CNS Agent Using Rodent Maze Models
This experimental research explores the therapeutic value of a new dual-target central nervous system (CNS) drug that concurrently regulates GABAergic and glutamatergic systems to treat co-occurring cognitive impairment and anxiety symptoms. Performed on thirty adults male Wistar rats, the study utilized proven behavioural paradigms Elevated Plus Maze (EPM) for anxiety and Morris Water Maze (MWM) for spatial learning along with post-mortem biochemical assays to examine acetylcholinesterase (AChE) activity and markers of oxidative stress like malondialdehyde (MDA) and superoxide dismutase (SOD). Results indicated significant, dose-dependent enhancements: high-dose treatment groups demonstrated increased open-arm exploration in EPM and reduced escape latencies with more time spent in target quadrants in MWM, indicating anxiolytic and cognitive-enhancing effects. Biochemically, a significant decrease in AChE and MDA levels and increased SOD activity validated enhanced cholinergic transmission and antioxidant defense. One-way ANOVA validated these results with high statistical significance (p
