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Welcome to the issue of Journal of Pharmaceutical Research and Integrated Medical Sciences. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.
We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.
As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.
Dr. Arpan Kumar Tripathi
Editor-in-Chief
Journal of Pharmaceutical Research and Integrated Medical Sciences
Botanical antioxidants like flavonoids and polyphenols offer promising natural UV protection but suffer from low SPF (
Vesicular drug delivery systems have revolutionized pharmaceutical technology by enhancing therapeutic efficacy, improving drug stability, and enabling targeted and controlled release. Among them, lipoidal and non-lipoidal vesicles represent two distinct yet complementary approaches in nanocarrier design. Lipoidal vesicles, such as liposomes, ethosomes, and transfersomes, are primarily composed of phospholipids and mimic biological membranes, offering excellent biocompatibility and encapsulation of lipophilic drugs. In contrast, non-lipoidal vesicular systems, including polymersomes, dendrimers, and other polymer-based carriers, utilize synthetic or natural polymers to achieve greater structural stability, tunable release profiles, and enhanced physicochemical versatility.
Cancer continues to pose a significant global health challenge, affecting nearly one in five individuals throughout their lifetime. While chemotherapeutic agents like doxorubicin play a crucial role in cancer treatment, their use is frequently accompanied by serious side effects, particularly nephrotoxicity. This review critically examines the renoprotective effects of flavonoids in counteracting doxorubicin-induced kidney damage, with a focus on evidence from preclinical animal models. Doxorubicin mediates its cytotoxic effects by intercalating into DNA and inducing the formation of reactive oxygen species (ROS), which lead to oxidative stress, apoptosis, and subsequent renal injury. A comprehensive literature search was conducted using databases including Google Scholar, Scopus, pubmed, Springer, Wiley Online Library, and sciencedirect, targeting articles published between 2014 and 2024. Keywords used included “flavonoids,” “doxorubicin,” “nephrotoxicity,” “Renoprotective,” and “animal model.” Flavonoids, a broad class of plant-derived polyphenols, are well recognized for their antioxidant, anti-inflammatory, and anticancer activities. Certain flavonoids, similar to quercetin, rutin, kaempferol, morin, luteolin, apigenin, hesperidin, naringenin, diosmin, and anthocyanins, have shown significant effectiveness in reducing kidney damage caused by doxorubicin. This review highlights the promising role of flavonoids as potential adjuvants in reducing chemotherapy-associated renal side effects and enhancing the safety profile of anticancer regimens.
The contamination of water sources with heavy metal ions, especially Cu²⁺, has been on the rise, and hence, there is a need to develop efficient and sustainable adsorbent materials. This study aims at synthesizing cellulose nanofiber (CNF)-enhanced hydrogels for Cu²⁺ ion adsorption to improve adsorption capacity, mechanical stability, and reusability. Hydrogels were synthesized through free radical polymerization, incorporating CNFs to enhance structural integrity and surface area. The characterization by FTIR, SEM, and swelling studies proved that hydrogels were successfully synthesized with improved porosity. The batch adsorption experiments revealed high Cu²⁺ removal efficiency for CNF-enhanced hydrogels and attained rapid equilibrium of adsorption under optimized pH and contact time conditions. Adsorption was based on the Langmuir isotherm and pseudo-second-order kinetics, with evidence of monolayer adsorption and a strong binding affinity. Regeneration studies confirmed multiple cycles of adsorption, indicating the sustainability potential of the hydrogel. These findings highlight the potential application of CNF-enhanced hydrogels in wastewater treatment, providing an eco-friendly and cost-effective solution for heavy metal remediation.
Gorlin-Goltz syndrome (GGS) is a hereditary cancer syndrome with dominant inheritance caused by mutations in the PTCH1 gene, responsible for encoding a transmembrane receptor that interacts with the SHH signaling protein. This Hedgehog signaling pathway is essential for cell division and growth, for controlling the development of vertebrates' organs, for differentiating fingers, and for the formation of the brain, spinal cord, eyes, and teeth. When the PTCH gene is homozygously inactivated, cancerogenesis ensues, resulting in the development of numerous basal cell carcinomas and other neoplasms. Other than major anomalies such as multiple basal cell carcinomas, odontogenic keratocysts of the jaw, multiple palmar or plantar pits, bilamellar calcifications of falx cerebri and tentorium, Bifid or fused, or markedly splayed ribs, more than 100 minor anomalies have been described so far. Radiological investigations and genetic testing plays a major role in early diagnosis of this syndrome. We have presented a 19-year-old male patient who presented with multiple odontogenic keratocyst and eventually diagnosed to be GGS. we have also summarized GGS anomalies recorded so far along with differential diagnosis.
